Date Updated

Monday, August 9, 2010

Usual Adult Dose for Pain

Oral: 2.5 to 10 mg every 3 to 12 hours.
IV, IM, subcutaneously: 2.5 to 10 mg every 3 to 6 hours.


Usual Adult Dose for Opiate Withdrawal

Initial Dose: 15 to 40 mg once a day. The oral route is preferred unless the patient is unable to ingest oral methadone, then parenteral form can be used. 5 to 10 mg additional doses may be given if symptoms of abstinence are distressing.
After one or two days, a 20% daily reduction in dose can usually be tolerated. Detoxification can usually be completed within 10 days.
Maintenance of opiate dependence: 20 to 120 mg/day.

Oral - Diskets:
Induction/Initial Dosing:
The initial methadone dose should be administered, under supervision, when there are no signs of sedation or intoxication, and the patient shows symptoms of withdrawal.

Initial dose: a single dose of 20 to 30 mg of methadone will often be sufficient to suppress withdrawal symptoms. The initial dose should not exceed 30 mg.

If same day dosing adjustments are to be made, the patient should be asked to wait two to four hours for further evaluation, when peak levels have been reached. An additional 5 to 10 mg of methadone may be provided if withdrawal symptoms have not been suppressed or if symptoms reappear. The total daily dose of methadone on the first day of treatment should not ordinarily exceed 40 mg. Dose adjustments should be made over the first week of treatment based on control of withdrawal symptoms at the time of expected peak activity (e.g., 2 to 4 hours after dosing). Dose adjustment should be cautious; deaths have occurred in early treatment due to the cumulative effects of the first several days dosing. Because diskets can be administered only in 10 mg increments, diskets may not be the appropriate product for initial dosing in many patients. Patients should be reminded that the dose will "hold" for a longer period of time as tissue stores of methadone accumulate.  Buy Methadone

Initial doses should be lower for patients whose tolerance is expected to be low at treatment entry. Loss of tolerance should be considered in any patient who has not taken opioids for more than five days. Initial doses should not be determined by previous treatment episodes or dollars spent per day on illicit drug use.


For Short-term Detoxification:
For patients preferring a brief course of stabilization followed by a period of medically supervised withdrawal, it is generally recommended that the patient be titrated to a total daily dose of about 40 mg in divided doses to achieve an adequate stabilizing level. Stabilization can be continued for 2 to 3 days, after which the dose of methadone should be gradually decreased. The rate at which methadone is decreased should be determined separately for each patient. The dose of methadone can be decreased on a daily basis or at two day intervals, but the amount of intake should remain sufficient to keep withdrawal symptoms at a tolerable level. In hospitalized patients, a daily reduction of 20% of the total daily dose may be tolerated. In ambulatory patients, a somewhat slower schedule may be needed. Because diskets can be administered only in 10 mg increments, diskets may not be the appropriate product for gradual dose reduction in many patients.


For Maintenance Treatment:
Patients in maintenance treatment should be titrated to a dose at which opioid symptoms are prevented for 24 hours, drug hunger or craving is reduced, the euphoric effects of self-administered opioids are blocked or attenuated, and the patient is tolerant to the sedative effects of methadone. Most commonly, clinical stability is achieved at doses between 80 to 120 mg/day.Buy Methadone




For Medically Supervised Withdrawal After a Period of Maintenance Treatment:
There is considerable variability in the appropriate rate of methadone taper in patients choosing medically supervised withdrawal from methadone treatment. It is generally suggested that dose reductions should be less than 10% of the established tolerance or maintenance dose, and that 10 to 14 day intervals should elapse between dose reductions. Because diskets can be administered only in 10 mg increments, it may not be the appropriate product for gradual dose reduction in many patients. Patients should be apprised of the high risk of relapse to illicit drug use associated with discontinuation of methadone maintenance treatment.


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Tuesday, October 6, 2009

Dosage and Administration

Conversion From Parenteral Methadone to Oral Methadone
Adults
PO Start with 1:2 dose ratio (eg, parenteral methadone 5 mg to oral methadone 10 mg).
Detoxification and Maintenance Treatment of Opiate Dependence
Adults
IV/IM/Subcutaneous/PO For detoxification and maintenance of opiate dependence, methadone should be administered in accordance with the treatment standards cited in the Code of Federal Regulation, Title 42, Section 8.12, including limitations on unsupervised administrations.
Induction
Adults   Buy Methadone


PO Start with 20 to 30 mg to suppress withdrawal symptoms. For same-day dosing adjustments, wait 2 to 4 h for further evaluation when peak levels are reached. An additional 5 to 10 mg may be administered if withdrawal symptoms have not been suppressed or if symptoms reappear (max, 40 mg the first day). Dose adjustments should be made over the first week of treatment based on control of withdrawal symptoms at the time of expected peak activity (eg, 2 to 4 h after dosing). Initial doses should be lower for patients whose tolerance is expected to be low at the beginning of treatment.
Initiation of Therapy in Opioid Nontolerant Patients
Adults
IV/IM/Subcutaneous/PO When used as the first analgesic in patients who are not already being treated with, and tolerant to, opioids, start with 2.5 to 10 mg every 8 to 12 h. Slowly titrate to effect. More frequent administration may be required during initiation in order to maintain adequate analgesia.
Maintenance  Buy Methadone

Adults
PO Most commonly, clinical stability is achieved at dosages between 80 and 120 mg/day. Titrate to a dose at which opioid symptoms are prevented for 24 h, drug hunger or craving is reduced, the euphoric effects of self-administered opioids are blocked or attenuated, and the patient is tolerant to the sedative effects of methadone.
Medically Supervised Withdrawal After a Period of Maintenance Treatment
Adults
PO It is generally suggested that the dose reductions should be less than 10% of the established tolerance or maintenance dose, and that 10- to 14-day intervals should elapse between dose reductions.
Short-Term Detoxification
Adults
PO Titrate patients to a total daily dose of about 40 mg in divided doses to achieve an adequate stabilization level. Continue stabilization for 2 to 3 days, after which the dose should be gradually decreased. The rate of decrease should be determined for each patient. The dose can be decreased on a daily basis or at 2-day intervals, but the amount of intake should remain sufficient to keep withdrawal symptoms at a tolerable level. In hospitalized patients, a daily reduction of 20% of the total daily dose may be tolerated. In ambulatory patients, a somewhat slower schedule may be needed.
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Adults
IV/PO Use the following guidelines for oral morphine to methadone conversion:
Total daily baseline oral morphine dose Morphine less than 100 mg
The estimated daily oral methadone requirement as a percent of total daily oral morphine dose is 20% to 30% (IV, 10% to 15%).

Thursday, January 31, 2008

Background Information of Methadone

 Buy Methadone
  it is a rigorously well-tested medication that is safe and efficacious for the treatment of narcotic withdrawal and dependence. For more than 30 years this synthetic narcotic has been used to treat opioid addiction. Heroin releases an excess of dopamine in the body and causes users to need an opiate continuously occupying the opioid receptor in the brain. Methadone occupies this receptor and is the stabilizing factor that permits addicts on methadone to change their behavior and to discontinue heroin use.

Thursday, December 27, 2007

What is the most important information I should know about methadone?

Taking methadone improperly will increase your risk of serious side effects or death. Even if you have used other narcotic medications, you may still have serious side effects from methadone. Follow all dosing instructions carefully.  Buy Methadone

Like other narcotic medicines, methadone can slow your breathing, even long after the pain-relieving effects of the medication wear off. Death may occur if breathing becomes too weak. Never use more methadone than your doctor has prescribed. Call your doctor if you think the medicine is not working.

Do not stop using and Buy Methadone

suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Do not drink alcohol while you are taking methadone. Dangerous side effects or death can occur when alcohol is combined with methadone.

Check your food and medicine labels to be sure these products do not contain alcohol. Methadone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.Buy Methadone

Thursday, October 25, 2007

What is Methadone?

METHADONE

Medication

Prices

Pharmacy

Methadone 10 MG. $2.50 Buy Methadone 10 MG.
Methadone is an opioid medication. Buy Methadone here. Methadone is similar to other opioids such as morphine, codeine, and heroin however, it produces less euphoric ("high") effects and therefore may be easier to stop taking. Buy Methadone

here. Methadone blocks the effects of opioids such as morphine, codeine, and heroin. 


How should I take Methadone?

Take methadone exactly as directed by your doctor. Buy Methadone

here. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.  here. The methadone tablets should be placed under the tongue and allowed to dissolve. Do not chew or swallow the tablets. 

Possible side effects from Methadone

Methadone can cause drug dependence. Buy Methadone

here. This means that withdrawal symptoms may occur if you stop using the medicine too quickly. Withdrawal symptoms may also occur at the start of treatment due to dependence on another drug. Methadone is not for occasional ("as needed") use.. Buy Methadone

Cautions when taking Methadone

Use Methadone with caution when driving, operating machinery, or performing other hazardous activities. Methadone may cause dizziness or drowsiness.  here. If you experience dizziness or drowsiness, avoid these activities while taking methadone. Do not take more methadone than is prescribed.


What happens if I overdose with Methadone?

Seek emergency medical attention if you suspect overdose with Methadone. Buy Methadone

here. Symptoms of a methadone overdose may include slow breathing, seizures, dizziness, weakness, loss of consciousness, coma, and small pupils.